Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1998-05-18
2000-02-22
MacMillan, Keith D.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, 530816, 530813, 530812, 530811, C07K 708
Patent
active
060281707
ABSTRACT:
A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation at those sites to encode nonreactive amino acids. Several novel strategies for coupling the hirudin analog to solid surfaces while simultaneously conserving antithrombogenic activity are disclosed.
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Breillatt Julian
Johnson Richard
Ku Cecilia S. L.
Barrett Joseph B.
Baxter International Inc.
Fuchs Joseph A.
MacMillan Keith D.
Wessendorf T. D.
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