Analogs of glycyl-prolyl-glutamate

Details Analogs of glycyl-prolyl-glutamate Analogs of glycyl-prolyl-glutamate

2011-01-04

2011-01-04

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S146000, C548S200000

Reexamination Certificate

active

07863304

ABSTRACT:
Embodiments of this invention include novel analogs of Glycyl-Prolyl-Glutamate (GPE) and compositions containing such analogs of GPE. Of these, certain analogs have modified proline residues. Other embodiments of this invention include uses of analogs of GPE to protect neural cells from degeneration and/or death in response to injury or disease. Disorders treatable with compounds and compositions of this invention include hypoxia/ischemia, toxic injury, and chronic neurodegenerative disorders including Parkinson's disease.

REFERENCES:
patent: 6682753 (2004-01-01), Alexi
patent: 7041314 (2006-05-01), Abood et al.
patent: 7605177 (2009-10-01), Gluckman et al.
Gluckman et al (2002): STN International HCAPLUS database, (Columbus, Ohio), Accession No. 2002:157813.
Zaczek et al (1993): STN International HCAPLUS database, (Columbus, Ohio), Accession No. 1993:617294.

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