Analogs of gastric inhibitory polypeptide and their use for...

Details Analogs of gastric inhibitory polypeptide and their use for... Analogs of gastric inhibitory polypeptide and their use for...

2005-07-26

2005-07-26

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C514S014800, C514S021800, C530S324000, C530S325000, C530S326000, C530S334000

Reexamination Certificate

active

06921748

ABSTRACT:
The present invention provides peptides which stimulate the release of insulin. The peptides, based on GIP 1-42, include substitutions and/or modifications which enhance and influence secretion and/or have enhanced resistance to degradation. The invention also provides a process of N terminally modifying GIP and the use of the peptide analogues for treatment of diabetes.

REFERENCES:
patent: 196 16 486 (1997-10-01), None
patent: 0869 135 (1998-10-01), None
Fujii et al. Studies on Peptides, CXXXIX. Solution Synthesis of a 42-Residue Peptide . . . Chemical and Pharmaceutical Bulletin. 1986. vol. 34, No. 6, pp. 2397-2410.
Chemical Abstracts, vol. 131 No. 1, Jul. 5, 1999, Columbus, Ohio (US), Abstract No. 944, O'Harte, Finnbarr P. M., et al: “NH2-terminally modified gastric inhibitory polypeptide exhibits aminopeptidase resistance and enhanced antihyperglycemic activity”.
Chem Abstract 127:341803d (1997) of DE 19616 486 A1.

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