Analogs of extended N-terminal somatostatin

Details Analogs of extended N-terminal somatostatin Analogs of extended N-terminal somatostatin

1981-04-29

1983-07-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125S, A61K 3700, C07C10352

Patent

active

043930506

ABSTRACT:
Somatostatin-28 has the formula: ##STR1## Analogs have been synthesized that are more potent than somatostatin-28, and these analogs or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals in the same manner as somatostatin. In the analogs, Leu may be substituted in the 8-position in combination with D-Trp in the 22-position and/or Tyr in the 25-position. D-Cys may also be substituted in the 28-position, and D-Ser may be substituted in the 27-position. Certain residues may also be deleted. D-Trp.sup.22 somatostation-28 has surprisingly been found to be insulin-selective when administered in vivo and is useful for the treatment of insulinoma.

REFERENCES:
patent: 4316891 (1982-02-01), Guillemin et al.
FEBS Letters, Jan. 1980, vol. 109, No. 1, Biochem, and Biophys. Res. Comm., vol. No. 95, No. 3, pp. 945-951, 8/14/80 Ling et al. "Solid Phase Synthesis of Somatostatin-28.
Biochem. and Biophys. Res. Comm., vol. 96, No. 2, pp. 725-734, 9/30/80, Bohlen et al. "Isolation and Amino Acid Composition of Two Somatostatin-Like Peptides from Ovine Hypothalamus": Somatostatin-28 and Somatostatin-25.

Affiliated with

Also associated with

Rating

Analogs of extended N-terminal somatostatin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analogs of extended N-terminal somatostatin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analogs of extended N-terminal somatostatin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-198406