Analogs of epothilone

Details Analogs of epothilone Analogs of epothilone

2007-01-30

2007-01-30

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S365000, C514S369000, C548S187000, C548S202000, C548S204000

Reexamination Certificate

active

10634537

ABSTRACT:
Designed epoxide and cyclopropane epothilone analogs with substituted side-chains are disclosed and characterized with respect to their biological activities against a series of human cancer cell lines. Among the several bioactive analogs, the epothilone B analog with a thiomethyl thiazole ring stands out as the most potent.

REFERENCES:
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