Analogs of dehydrophenylahistins and their therapeutic use

Details Analogs of dehydrophenylahistins and their therapeutic use Analogs of dehydrophenylahistins and their therapeutic use

2011-04-05

2011-04-05

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S406000

Reexamination Certificate

active

07919497

ABSTRACT:
Compounds represented by the following structure (II) are disclosed:as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

REFERENCES:
patent: 5607934 (1997-03-01), Tone et al.
patent: 5733888 (1998-03-01), Carver et al.
patent: 5852018 (1998-12-01), Bryans et al.
patent: 5874443 (1999-02-01), Kiely et al.
patent: 5886210 (1999-03-01), Rayle et al.
patent: 5891877 (1999-04-01), Brocchini et al.
patent: 5922683 (1999-07-01), Or et al.
patent: 6069146 (2000-05-01), Fenical et al.
patent: 6350759 (2002-02-01), Casara et al.
patent: 6358957 (2002-03-01), Fukumoto et al.
patent: 6500825 (2002-12-01), Lan et al.
patent: 6506787 (2003-01-01), Fujishita et al.
patent: 6509331 (2003-01-01), Audia et al.
patent: 6583143 (2003-06-01), Haddach
patent: 6713480 (2004-03-01), Fukumoto et al.
patent: 7026322 (2004-05-01), Hayashi et al.
patent: 6972289 (2005-12-01), Kanzaki et al.
patent: 7064201 (2006-06-01), Hayashi et al.
patent: 7674903 (2010-03-01), Hayashi et al.
patent: 2002/0143021 (2002-10-01), Fukumoto et al.
patent: 2004/0102454 (2004-05-01), Hayashi et al.
patent: 2005/0090667 (2005-04-01), Hayashi et al.
patent: 2005/0197344 (2005-09-01), Palladino et al.
patent: 2006/0079534 (2006-04-01), Kanzaki et al.
patent: 2006/0167010 (2006-07-01), Hayashi et al.
patent: 2006/0217553 (2006-09-01), Hayashi et al.
patent: 2006/0223822 (2006-10-01), Hayashi et al.
patent: 2006/0223823 (2006-10-01), Hayashi et al.
patent: 2007/0078138 (2007-04-01), Palladino et al.
patent: 2008/0221122 (2008-09-01), Palladino et al.
patent: 2 403 790 (2001-07-01), None
patent: 0655060 (1998-01-01), None
patent: 1 264 831 (2002-11-01), None
patent: 2143823 (1985-02-01), None
patent: 5009164 (1993-01-01), None
patent: 10-130266 (1998-05-01), None
patent: WO 95/21832 (1995-08-01), None
patent: WO 96/20190 (1996-07-01), None
patent: WO 99/38844 (1999-08-01), None
patent: WO 99/48889 (1999-09-01), None
patent: WO 01/53290 (2001-07-01), None
patent: WO 2004/054498 (2004-07-01), None
patent: WO 2005/077940 (2005-08-01), None
patent: WO/01/53290 (2009-03-01), None
Abstracts of The 1999 Joint Chubu and Kansai Branch Conference and Symposium of Japan Society for Bioscience, Biotechnology, and Agrochemistry, p. 48 (1999) (in Japanese).
Abstracts of The 1999 Joint Chubu and Kansai Branch Conference and Symposium of Japan Society for Bioscience, Biotechnology, and Agrochemistry, p. 48 (1999) (translated to English).
Akerlund et al., “Diketopiperazine-Based Polymers from Common Amino Acids,” Journal of Applied Polymer Science (2000), 78 (12), 2213-2218.
Amendment and Response to Written Opinion submitted in International Application No. PCT/US03/024232 on Jan. 20, 2005.
Asahina, T. Bulletin of the Chemical Society of Japan, vol. 5, pp. 354-365 (1930).
Augustin, M. “Die Umsetzung des 2,5-Diketopiperazins mit Aldehyden und Nitrosoverbindungen” Journal für Praktische Chemie, vol. 32(4) pp. 158-166 (1966).
European Supplementary Search Report dated Oct. 11, 2005 for Application No. 00963011.2-2117 PCT/JP0006807.
Fukushima et al., “Biological Activities of Albonoursin,” J. Antibiotics, 26: 175 (1973).
Goldfarb et al., “Synthesis of β-2-thienylalanine” Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, pp. 98-100 (1958), as abstracted by CAPLUS.
Hayashi, et al., “Total Synthesis of Anti-microtubule Diketopiperazine Derivatives: Phenylahistin and Aurantiamine,”J. Org. Chem. 2000, 65: 8402-8405.
Hyun, et al., “Valine dehydrogenase fromStreptomyces albus: gene cloning, heterologous expression and identification of active site by site-directed mutagenesis,”FEMS Microbiology Letters182 (2000) 29-34.
International Search Report, International Application No. PCT/US03/24232, Sep. 27, 2004.
Kanoh et al., “(-)- Phenylahistin: A New Mammalian Cell Cycle Inhibitor Produced by Aspergillus USTUS,” Bioorganic & Medicinal Chemistry Letters, 7: 2847-2852 (1997).
Kanoh et al., “Synthesis and Biological Activities of Phenylahistin Derivatives,” Bioorganic & Medicinal Chemistry, 7: 1451-1457 (1999).
Kanoh et al., “Antitumor Activity of Phenylahistin in Vitro and in Vivo,” Bioscience Biotechnology Biochemistry, 63: 1130-1133 (1999).
Kanoh et al., “(-)-Phenylahistin Arrests Cells in Mitosis by Inhibiting Tubulin Polymerization,”The Journal of Antibiotics, 52: 134-141 (1999).
Kanzaki et al., A Novel Potent Cell Cycle Inhibitor Dehydrophenylahistin-Enzymatic Synthesis and Inhibitory Activity toward Sea Urchin Embryo,The Journal of Antibiotics, 55: 1042-1047 (Dec. 2002).
Kanzaki et al., “Effective Production of Dehydro Cyclic Dipeptide Albonoursin Exhibiting Pronuclear Fusion Inhibitory Activity, I. Taxonomy and Fermentation”The Journal of Antibiotics, 52: 1017-1022 (1999).
Kanzaki et al., “Effective Production of Dehydro Cyclic Dipeptide Albonoursin Exhibiting Pronuclear Fusion Inhibitory Activity, II. Biosynthetic and Bioconversion Studies”The Journal of Antibiotics, 53: 58-62 (2000).
Kanzaki, et al., “Novel Cyclic Dipeptide Dehydrogenase and Assay Method for Its Activity,” Scientific Reports of the Faculty of Agriculture, Okayama University, 88:7-11 (1999) (in Japanese).
Kanzaki, et al., “Novel Cyclic Dipeptide Dehydrogenase and Assay Method for Its Activity,” Scientific Reports of the Faculty of Agriculture, Okayama University, 88:7-11 (1999). (translated to English).
Kanzaki et al., “Enzymatic Synthesis of Physiologicall Actve Substances Utilizing a Novel System for the Synthesis of Diketopiperazines Comprising Dehydroamino Acids as Constituents”Abstracts of Papers Presented at the 1999 Meeting of the Society for ActinomycetesJapan, p. 42 (1999).
Kanzaki et al., “Enzymatic dehydrogenation of cyclo(L-Phe-L-Leu) to a bioactive derivative, albonoursin,”Journal of Molecular Catalysis B: Enzymatic6(1999) 265-270.
Kobayashi et al., “Microtubule Assembly Regulatorss of Microbial Origin”Abstract of Paper Read at the 1989 Symposium on the Chemistry of Natural Products, p. 51 (1989).
Kopple et al., “A Convenient Synthesis of 2,5-Piperazinediones1a,”The Journal of Organic Chemistry, 33: 862-864 (1967).
Küster and Köppenhofer, “Über eininge Pyrrolderivate” Z. Physiol, Chem., vol. 172, pp. 126-137 (1927).
Niemann et al, “The Synthesis of the Three Isomeric dl-β-Pyridylalanines” Journal of the American Chemical Society, vol, 64(7), pp. 1678-1682 (1942).
Nitecki et al., “A Simple Route to Sterically Pure Diketopiperazines1,”The Journal of Organic Chemistry, 33: 864-866 (1968).
PCT International Preliminary Examination Report, International Application No. PCT/JP00/06807, Dec. 7, 2001.
PCT International Preliminary Report on Patentability, International Application No. PCT/US2005/003636, mailed Aug. 17, 2006.
PCT International Search Report from PCT/JP00/06807, mailed Jul. 19, 2005.
PCT International Search Report and Written Opinion from PCT/US2006/036736, mailed Feb. 5, 2007.
“Prosecution History of U.S. Appl. No. 10/632,531.”
“Prosecution History of U.S. Appl. No. 10/181,786.”
“Prosecution History as of Mar. 27, 2009 of U.S. Appl. No. 11/051,268, filed Feb. 4, 2005.”
“Prosecution History as of Mar. 27, 2009 of U.S. Appl. No. 11/448,924, filed Jun. 7, 2006.”
Saito et al., Synthesis of novel octahydro-1, 5-imino-3-benzazocin-4, 7, 10-trione derivatives having a methyl group at the C-2 position as ABC ring models of saframycins.Chemical&Pharmaceutical Bulletin(1997), 45(7), 1120-1129.
Sezaki and Shoten, “Drug Delivery Systems”,Drug Development, 13: 116, Table 2. 29, (Jul. 1989).
Yokio et al, “Neihumicin, A New Cytotoxic Antibiotic From Micromonospora Neihuensis” The Journal of Antibiotics, vol, 4

Affiliated with

Also associated with

Rating

Analogs of dehydrophenylahistins and their therapeutic use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analogs of dehydrophenylahistins and their therapeutic use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analogs of dehydrophenylahistins and their therapeutic use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2722326