Analogs of cytochalasin B as radiopharmaceuticals for nuclear im

Details Analogs of cytochalasin B as radiopharmaceuticals for nuclear im Analogs of cytochalasin B as radiopharmaceuticals for nuclear im

1994-05-24

1995-04-18

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 185, 424 189, A61K 4900

Patent

active

054076587

ABSTRACT:
Analogs of cytochalasin B are used as radiopharmaceuticals to provide an image for the nuclear imaging of glucose transport across cell membranes. Like cytochalasin B, the analogs bind specifically to glucose transport protein, and in doing so, serve as markers indicating the amount of glucose transport protein present on the surfaces of cells. The analogs differ from cytochalasin B by the inclusion of a radionuclide in the region of the terminal phenyl group on cytochalasin B, where the radionuclide does not interfere with the binding specificity of the analog. Disclosed herein are such analogs as well as analogs with which readily accept radionuclides at the desired location on the structure, either by conjugation or substitution.

REFERENCES:
patent: 4765972 (1988-08-01), Safa et al.
Thorens et al., "Molecular Physiology of Glucose Transporters," Diabetes Care, vol. 13, (3), Mar. 1990, pp. 209-218.

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