Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing
Patent
1993-06-08
1994-08-30
Stoll, Robert L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Radioactive metal containing
548431, 534 14, C07F 1300, C07D49102
Patent
active
053429265
ABSTRACT:
Analogs of cytochalasin B are used as radiopharmaceuticals to provide an image for the nuclear imaging of glucose transport across cell membranes. Like cytochalasin B, the analogs bind specifically to glucose transport protein, and in doing so, serve as markers indicating the amount of glucose transport protein present on the surfaces of cells. The analogs differ from cytochalasin B by the inclusion of a radionuclide in the region of the terminal phenyl group on cytochalasin B, where the radionuclide does not interfere with the binding specificity of the analog. Disclosed herein are such analogs as well as analogs with which readily accept radionuclides at the desired location on the structure, either by conjugation or substitution.
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Chapman Lara E.
Stoll Robert L.
The Regents of the University of California
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