Analogs of carbonic anhydrase inhibitors and their use as topica

Details Analogs of carbonic anhydrase inhibitors and their use as topica Analogs of carbonic anhydrase inhibitors and their use as topica

1990-06-11

1992-10-20

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548139, C07D285135, A61K 3141

Patent

active

051570440

ABSTRACT:
Analogs are prepared of the carbonic anhydrase inhibitors methazolamide, and dichlorphenamide. The analogs link a cleavable functional group to the pharmacologically active carbonic anhydrase inhibitor resulting in compounds of improved corneal permeability, which are non-irritable to the eye and which are effective topically to inhibit intraocular pressure.

REFERENCES:
patent: 5010204 (1991-04-01), Antonaroli
Maren, J. Pharmacol. Exp. Ther. 241, 56,(1987) Abstract.
Vaughan, J. Org. Chem. 21, 700(1956) Abstract.

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