Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-10-16
2007-10-16
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S229800, C514S375000, C540S456000, C540S461000, C540S462000
Reexamination Certificate
active
11022057
ABSTRACT:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
REFERENCES:
patent: 4261989 (1981-04-01), Sasaki et al.
patent: 5387584 (1995-02-01), Schnur
patent: 5932566 (1999-08-01), Schnur et al.
patent: 6872715 (2005-03-01), Santi et al.
patent: 2006/0205705 (2006-09-01), Ross et al.
patent: 2106111 (1983-07-01), None
patent: WO 93/14215 (1993-07-01), None
patent: WO93/14215 (1993-07-01), None
patent: WO95/01342 (1995-01-01), None
patent: WO 03/013430 (2003-02-01), None
patent: WO 03/026571 (2003-04-01), None
patent: WO 03/066005 (2003-08-01), None
patent: WO-2005/095347 (2005-10-01), None
patent: WO 2007/001049 (2007-01-01), None
Hu, Z. et al., “Isolation and Characterization of Novel Geldanamycin Analogues”,Journ. Antibiot., 57(7):421-428 (Jul. 2004).
Kelland, L. R. et al., “DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino, 17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90”,Journ. of the Nat. Cancer Inst., 91(22):1940-1949 (Nov. 17, 1999).
Schnur, R. C. et al., “Inhibition of the Oncogene Product p. 185erbB-2in Vitro and in Vivo by Geldanamycin and Dihydrogeldanamycin Derivatives”,J. Med. Chem., 38:3806-3812 (1995).
International Search Report dated Apr. 25, 2005.
Clevenger, R. C. et al., “Design, Synthesis, and Evaluation of a Radicicol and Geldamycin Chimera, Radamide”,Organic Letters, 6(24);4459-4462 (2004).
Guo, W. et al., “Formation of 17-Allylamino-Demethoxygeldanamycin (17-AAG) Hydroquinone by NAD(P)H:Quinone Oxireductase 1: Role of 17-AAG Hydroquinone in Heat Shock Protein 90 Inhibition”,Cancer Res., 65(21:10006-10015 (Nov. 21, 2005).
Mitsiades, C. S. et al., “Antimyeloma activity of heat shock protein-90 inhibition”,Blood, 107(3):1092-1100 (Feb. 1, 2006).
Adams Julian
Evangelinos Asimina T. Georges
Gao Yun
Grenier Louis
Pak Roger H.
Foley & Hoag LLP
Gordon Dana M.
Infinity Pharmaceuticals Inc.
Kifle Bruck
LandOfFree
Analogs of benzoquinone-containing ansamycins and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Analogs of benzoquinone-containing ansamycins and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analogs of benzoquinone-containing ansamycins and methods of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3892745