Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2008-05-20
2008-05-20
Kifle, Bruck (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C540S461000, C540S462000
Reexamination Certificate
active
07375217
ABSTRACT:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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Adams Julian
Evangelinos Asimina T. Georges
Gao Yun
Grenier Louis
Pak Roger H.
Foley & Hoag LLP
Infinity Pharmaceuticals Inc.
Kifle Bruck
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