Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2004-06-18
2009-12-01
Oh, Taylor Victor (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S766000, C560S006000
Reexamination Certificate
active
07625947
ABSTRACT:
This invention relates to novel AKBA analogs of the formula I given below:Where in R1, R2, R3, R4and R5in each of the said analogs are:1. R1═OCHO, R2═H, R3═COOH, R4& R5═O2. R1═OCOCH2Cl, R2═H, R3═COOH, R4& R5═O3. R1═5′-O-methylgalloyloxy, R2═H, R3═COOH, R4& R5═O4. R1═OCOCH2CH2COOH, R2═H, R3═COOH, R4& R5═O5. R1═8′,9′-Dihydro-4′-hydroxycinnamoyloxy, R2═H, R3═COOH, R4& R5═O6. R1═4′-Hydroxycinnamoyloxy, R2═H, R3═COOH, R4& R5═O7. R1═3′,4′-Dimethoxycinnamoyloxy, R2═H, R3═COOH, R4& R5═O8. R1═3′,4′-Dihydroxy-5′-methoxycinnamoyloxy, R2═H, R3═COOH, R4& R5═O9. R1═OCOCH2NH(tert-BOC), R2═H, R3═COOCH3, R4& R5═O10. R1═OCOCH2NH2HCl, R2═H, R3—COOH, R4& R5═O11. R1═OCOCH(CH3)NH2HCl, R2═H, R3═COOH, R4& R5═O12. R1═H, R2═OH, R3═COOCH3, R4& R5═O13. R1═H, R2═Br, R3COOCH3, R4& R5═O14. R1═CN, R2═H, R3═COOCH3, R4& R5═O15. R1═SH, R2═H, R3═COOCH3, R4& R5═O16. R1& R2═N(OH), R3═COOCH3, R4& R5═O17. R1& R2═H & OCOCH3R3═H, R4& R5═O18. R1═OCOCH3, R2═H R3═COOCH2CH2N(CH3)2, R4& R5═O19. R1═OCOCH3, R2═H R3═CONH2, R4& R5═O20. R1═OCOCH3, R2═H, R3═CONHNH2, R4& R5═O21. R1═OCOCH3, R2═H, R3═CONHCH2CH2NH2, R4& R5═O22. R1═OCOCH3, R2═H, R3═CONHCH2CH2OH, R4& R5═O23. R1═OCOCH3, R2═H, R3═CON(CH2CH2)2NH, R4& R5═O24. R1═OCOCH3, R2═H R3═NCO, R4& R5═O25. R1═OCOCH3, R2═H R3═NH2, R4& R5═O26. R1═OCOCH3, R2═H R3═CN, R4& R5═O27. R1═OH, R2═H R3═COOH, R4& R5═OH & HThese compounds exhibited 5-Lipoxigenase inhibitory properties and these compounds may be used in pharmaceutical compositions for therapeutic applications against a variety of inflammations and hypersensitivity-based human diseases including asthma, arthritis, bowel diseases such as ulcerative colitis and circulatory disorders such as shock and ischaemia. These compounds also inhibited the growth of Brine Shrimp in cultures, which may be considered as a positive indication for cytotoxicity and antitumor activity.
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Savoir et al , Triterpenes. XI. Presence of 11-keto-B-boswellic acid in Incense, 1967, bulletin des Brussels chimiques Belges, 76(5-6), 368-70, ( two pages of abstract ).
International Search Report mailed on Mar. 18, 2005.
Gokaraju Ganga Raju
Gokaraju Rama Raju
Golakoti Trimurtulu
Gottumukkala Venkata Subbaraju
Laila Nutraceuticals
Oh Taylor Victor
Rader & Fishman & Grauer, PLLC
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