Analogs of [1,7-di-alanine, des-19-leucine]calcitonin

Details Analogs of [1,7-di-alanine, des-19-leucine]calcitonin Analogs of [1,7-di-alanine, des-19-leucine]calcitonin

1987-04-21

1989-04-11

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

C07K 736

Patent

active

048208043

ABSTRACT:
New hypocalcaemic peptides are disclosed of the formula ##STR1## wherein X represents H for the replacement of the N alpha amino group or acyl groups for the acylation of the N alpha amino group, the N-alpha amino group. The acyl groups are carboxylic acids especially formic, acetic, propionic, buteric, valeric, hexanoic, heptanoic, octanoic, and nonanoic acids or their respective isomers, L-lactic acid and the half amides of malonic, succinic, glutaric and adipic acids. Y is L-valine, glycine, L-methionine, L-alanine, L-leucine or L-isoleucine.

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patent: 4632978 (1986-12-01), Seyler et al.
patent: 4639511 (1987-01-01), Orlowski et al.

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