Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1981-04-22
1983-03-22
Ramsuer, Robert W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
546242, 546243, 546244, 564 33, C07D24522, C07C13302
Patent
active
043776876
ABSTRACT:
This invention relates to compounds having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, acyl, trifluoroacetyl, straight chained and branched alkyl groups with up to 6 carbon atoms, such alkyl groups with up to 3 substituents selected from the group consisting of OH, OSO.sub.2 CH.sub.3, COOH, COOR, CONH.sub.2 and Hal, where R is an alkyl group with up to 6 carbon atoms, and R.sub.1 and R.sub.2 together form a heterocyclic ring containing 4 to 6 carbon atoms and optionally further heteroatoms and such rings with up to 3 substituents selected from the group consisting of lower alkyl, OH, COOH, COOR, CONH.sub.2, where R has the above meaning, the chloroethyl nitrosoureido group and Hal, and Hal is selected from the group consisting of chlorine and fluorine, which heterocyclic ring is not the para-methyl piperazine group, said nitroso ureas having a tumor inhibiting effect.
This invention also related to a method of inhibiting transplanted tumors which comprises treating a tumor-afflicted subject with one of the foregoing 1,3 - disubstituted nitroso ureas. It also involves a method of preparing such new compounds by reacting N-(2-halogenethyl)-N-nitrosocarbamoylazide with hydrazine or a monocyclic N-amino heterocyclic or their derivatives.
REFERENCES:
Eisenbrand, Chemical Abstracts, vol. 93 (1980) No. 132, 466m (Abstract of Germ. Offen, 2,845,574, Apr. 24, 1980).
Eisenbrand et al., J. Cancer Res. Clin. Oncol. vol. 95 (1979) pp. 43-49.
Ramsuer Robert W.
Schaffer Murray
Stiftung Deutsches Krebsforschungszentrum
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