Analog of peptidase substrates

Details Analog of peptidase substrates Analog of peptidase substrates

1991-09-05

1992-05-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, 530331, C07K 508, C07K 510

Patent

active

051149273

ABSTRACT:
This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with a difluoromethylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced with a terminal amine function, said novel analogs having the property of inhibiting renin and which are useful in the treatment of hypertension.

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