Analog of haemophilus hin47 with reduced protease activity

Details Analog of haemophilus hin47 with reduced protease activity Analog of haemophilus hin47 with reduced protease activity

1995-06-07

1999-02-09

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435220, 4353201, 4352523, 435325, 435419, 935 10, 935 14, 536 232, 536 237, C12N 952, C12N 1531, C12N 1557

Patent

active

058693025

ABSTRACT:
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.

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