Analog of haemophilus Hin47 with reduced protease activity

Details Analog of haemophilus Hin47 with reduced protease activity Analog of haemophilus Hin47 with reduced protease activity

1998-06-30

2000-11-28

Martinell, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435220, 514 12, A61K 3902

Patent

active

06153580&

ABSTRACT:
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.

REFERENCES:
patent: 5506139 (1996-04-01), Loosmoore et al.
patent: 5935573 (1999-08-01), Loosmoore et al.
patent: 5939297 (1999-08-01), Loosmoore et al.
patent: 6020183 (2000-02-01), Loosmore et al.
1. Zangwill et al, 1993 MMWR 42:1-15.
2. Schoendorf et al, 1994 Pediatrics 93:663-8.
3. Brenner S., 1988 Nature 334:528-530.
4. O'Hagan 1992 Clin. Pharmokinet. 22:1-10.
5. Ulmer et al, 1993 Curr. Opinion. Invest. Drugs 2:983-989.
6. Chang et al, 1978 Nature 275:617-624.
7. Goeddel et al 1980 Nucl. Acid. Res. 8:4057-4074.
8. Harkness et al, 1992 J. Bacteriol. 174:2425-2430.
9. Loeb M.R., 1987 Infec. Immun. 55:2612-2618.
10. Holmes and Quigley 1981. Analyt. Biochem. 114:193-197.
11. Young and Davis, 1983 Proc. Natl. Acad. Sci. USA 80: 1194-1196.
12. Panezutti et al, 1993 Infec. Immun. 61:1867-1872.
13. Lipinska et al, 1985 Bacteriol. 171:1574-1584.
14. Barenkamp et al, 1986 Infect. Immun. 52:572-578.
15. Crowl et al, 1985 Gene 38:31-38.

Affiliated with

Also associated with

Rating

Analog of haemophilus Hin47 with reduced protease activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analog of haemophilus Hin47 with reduced protease activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analog of haemophilus Hin47 with reduced protease activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1725892