Analog of Haemophilus Hin47 with reduced protease activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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4242561, A61K 39102, A61K 31495, A01N 4348

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active

059624302

ABSTRACT:
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases (caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.

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Brenner et al, 1988 Nature 334:528-530.
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Holmes and Quigley 1981, Analyt. Biochem. 114:193-197.
Young and Davis 1985, Gene 38:31-38.
Panezutti et al, 1993 Infec. Immun. 61:1867-72.

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