Analog of haemophilus Hin47 with reduced protease activity

Details Analog of haemophilus Hin47 with reduced protease activity Analog of haemophilus Hin47 with reduced protease activity

1998-05-08

2000-02-01

Chin, Christopher L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

424 9463, 42419711, 4242561, 435 71, 435 691, 435 693, 435220, 4352521, 4352523, 43525233, C12N 112, A61K 3848, A61K 39385, G01N 3353, C12P 2106

Patent

active

060201835

ABSTRACT:
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.

REFERENCES:
patent: 5665353 (1997-09-01), Loosmore et al.
Zangwill et al, 1993 MMWR 42:1-15.
Schoendorf et al, 1994 Pediatrics 93:663-8.
Brenner S., 1988 Nature 334:528-530.
Chang et al, 1978 Nature 275:617-624.
Barenkamp et al, 1986 Infect. Immun. 52:572-578.

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