Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-06-02
1977-06-14
Moyer, Donald B.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424274, A61K 31485, A61K 3140
Patent
active
040297985
ABSTRACT:
An alalgetic composition which comprises, as an active ingredient, a therapeutically effective amount of a synergistic mixture of an indole-3-acetic acid derivative of the formula, ##STR1## wherein R is a halobenzoyl, piperonyloyl or cinnamoyl group and R.sub.1 is a 5-methoxy or 5,6-methylenedioxy group; and a narcotic or anti-narcotic analgesic selected from the group consisting of a compound of the formula, ##STR2## wherein R.sub.2 and R.sub.3 are each a C.sub.1 - C.sub.3 alkyl group and R.sub.4 is a 4-(4-fluorophenyl)-4-oxobutyl, cyclopropylmethyl or 3-methyl-2-butenyl group; a compound of the formula, ##STR3## wherein R.sub.5 is a hydrogen atom or a C.sub.1 - C.sub.3 alkyl group; a compound of the formula, ##STR4## and a compound of the formula, ##STR5## wherein R.sub.6 is a C.sub.1 - C.sub.3 alkyl group; and a pharmaceutically acceptable carrier or diluent and its preparation and a method of obtaining analgesia which comprises administering the same to a patient.
REFERENCES:
patent: 3161654 (1964-12-01), Shen
patent: 3250678 (1966-05-01), Archer
patent: 3551446 (1970-12-01), Yamamoto et al.
patent: 3576800 (1971-04-01), Yamamoto et al.
patent: 3812112 (1974-05-01), Kemura et al.
patent: 3833595 (1974-09-01), Atsumi et al.
The Merck Index, 8th Ed., p. 794, Published by Merck & Co. Inc., Rahway, N. J. (1968).
Inukai Toshiya
Koga Yoshihiko
Yamamoto Hisao
Moyer Donald B.
Sumitomo Chemical Company Limited
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