Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-12-10
2000-05-16
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142265, 514406, 514473, A61K 31495, A61K 3150, A61K 3154, A61K 31415, A61K 3134
Patent
active
060637838
ABSTRACT:
A class of substituted 7,8-ring fused 1,2,4-triazolo[4,3-b]pyridazine derivatives as shown in Formula I, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 6-position, are selective ligands for GABA.sub.A receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of pain. ##STR1##
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Castro Pineiro Jose Luis
Hill Raymond George
Durette Philippe L.
Jarvis William R. A.
Lee Shu M.
Merck Sharp & Dohme Ltd.
Rose David L.
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