Analgesic thiomorpholins their preparation, and pharmaceutical c

Details Analgesic thiomorpholins their preparation, and pharmaceutical c Analgesic thiomorpholins their preparation, and pharmaceutical c

1989-08-22

1991-06-04

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142278, 5142282, 514252, 514255, 514256, 514307, 514361, 514385, 514397, 514406, 544 60, 544 61, 544 62, 544238, 544330, 544405, 544111, 544359, 546104, 546139, 546176, 546208, 546268, 548127, 548255, 548336, 548518, 549 74, 549491, A61K 3154, C07D41700, C07D41702, C07D41714

Patent

active

050214136

ABSTRACT:
Analgesic compounds are of the general formula (I): ##STR1## in which, R.sup.1 and R.sup.2 each represents hydrogen or C.sub.1 -C.sub.6 alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a heterocycle; E represents methylene, sulfur, oxygen or imino group optionally substituted with C.sub.1 -C.sub.6 alkyl or aralkyl; ring A is aryl or heteroaryl ring, optionally substituted; R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.4 is hydrogen or R.sup.3 and R.sup.4 together represent a group of formula (IV):

REFERENCES:
patent: 3917617 (1975-11-01), Razdan et al.
patent: 4339576 (1982-07-01), Zenitz
patent: 4774241 (1988-09-01), Tatsuoka et al.
Wu et al, "Phenyl Alanyl Perhydro Thiazine . . . ", CA 110:24292n (1989).
Wu, S. et al., "Phenyl Alanyl Perhydro . . . ", CA 110:24293 (1989).

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