Analgesic properties of fedotozine

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514649, A61K 31135

Patent

active

053896866

ABSTRACT:
Process for the treatment of painful syndromes, especially local and/or visceral, consisting in the parenteral or topical administration of a therapeutically effective quantity of the (-) tartrate of (+)-(R)-1-[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-prop ylamine.

REFERENCES:
Pascaud et al., Effects of Fedotozine on Gastrointestinal Motility in Dogs: Mechanism of Action and Related Pharmacokinetics, J. Pharm. Pharmacol. 42:546-552 (1990).
Bost et al., Effect of Fedotozine on Esophageal Motility in Healthy Volunteers Eur. J. Gastroenterol Hepatol, vol. 3 Suppl. 1 p. S-13 (1991).
Homerin et al., Efficacy of Fedotozine in Non-ulcer Dyspepsia, in World Congress of Gastroenterology, Sydney, 26-31 Aug., (1990) Abingdon: The Medicine Group (UK) Ltd., Abstract p. 455.
Karaus et al., Effect of Fedotozine on Postprandial Intestinal Motility and Orocecal Transit Time in Humans, J. Gastrointest. Motil. Vol 3 No. 3, 186 (1991).
Coffin et al., Fedotozine Increases Threshold of Discomfort to Gastric Distension in Healthy Subjects; Gastoenterology, 102,4 (1992) p. A437.
Freye, Opioid Agonists, Antagonists and Mixed Narcotic Analgesics; Drugs of Today, U. 25 No. 11 (1989) pp. 741-754.
Koster et al., Acetic Acid for Analgesic Screening, Fed. Proc. 18, p. 412 (1959).
Bentley et al., Br. J. Pharm. 73 (1981) pp. 325-332.
Hughes et al. Neuropeptides, Arzneim-Forsch Aug. Res., 42(1) Nr. 2a (1992) pp. 250-255.
Horwell, Kappa Opioid Analgesics, Drugs of the Future, 13 No. 12 pp. 1061-1071 (1988).
Costello et al., A Novel Series of Potent and Selective Agonists at the Opiod K-receptor, Euro. J. Pharm. 151 (1988) 475-48).
Kappa Agonists Making Progress as Novel Analgesics, SCRIP, No. 1697, (Mar. 4, 1992) p. 22.
B. Coffin et al., Effets de la fedotozine sur la sensibilite gastrique evalues par le barostat electronique chez l'homme sain, Gastroenterol. Clin. Biol. 16, A31 (Mar. 1992).
J. R. Malagelada, Am J. Physiol., 248 G229-237 (1985).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Analgesic properties of fedotozine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analgesic properties of fedotozine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analgesic properties of fedotozine will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-288656

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.