Analgesic peptides from venom of grammostola spatulata and use t

Details Analgesic peptides from venom of grammostola spatulata and use t Analgesic peptides from venom of grammostola spatulata and use t

1996-12-30

1998-07-07

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, 600 26, 530300, 530324, 530855, 530858, 435 691, A61K 3800, A01N 3718, A61M 2100, C07C24500

Patent

active

057768960

ABSTRACT:
The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence of SEQ ID. NO.:1 or SEQ ID NO: 2. The invention further provides a purified peptide having the amino acid sequence of SEQ ID NO: 1. The peptides of SEQ ID NO.: 1 and SEQ ID NO.: 2 can also be used in methods for identifying compounds having analgesia-inducing activity.

REFERENCES:
patent: 4925654 (1990-05-01), Jackson et al.
patent: 5064657 (1991-11-01), Jackson et al.
patent: 5122596 (1992-06-01), Phillips et al.
patent: 5196204 (1993-03-01), Jackson et al.
patent: 5281693 (1994-01-01), Jackson et al.
Lampe et al., "Isolation and Pharmacological Characterization of .omega.-Grammotoxin SIA, a Novel Peptide Inhibitor of Neuronal Voltage-Sensitive Calcium Channel Responses", Molecular Pharmacology, 44:451-460, May 18, 1993.

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