Analgesic peptides from venom of Grammostola spatulata and use t

Details Analgesic peptides from venom of Grammostola spatulata and use t Analgesic peptides from venom of Grammostola spatulata and use t

1998-06-19

1999-03-02

Tsang, Cecilia J.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

530324, 514 12, 436518, G01N 3353, C07K 1400

Patent

active

058770267

ABSTRACT:
The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence of SEQ ID. NO.: 1 or SEQ ID NO: 2. The invention further provides a purified peptide having the amino acid sequence of SEQ ID NO: 1. The peptides of SEQ ID NO.: 1 and SEQ ID NO.: 2 can also be used in methods for identifying compounds having analgesia-inducing activity.

REFERENCES:
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patent: 5122596 (1992-06-01), Phillips et al.
patent: 5196204 (1993-03-01), Jackson et al.
patent: 5281693 (1994-01-01), Jackson et al.
Keith et al. `Comparatie Actions of Synthetic .gamma.-Grammotoxin SIA an Synthetic .gamma.-Aga-IVA on Neuronal Calcium Entry and Evoked Release of Neurotransmitters In Vitro and In Vivo`, Neuropharmacology, (1995 Nov.) 34 (11) 1515-28.
Lampe et al., "Isolation and Pharmacological Characterization of .omega.-Grammotoxin SIA, a Novel Peptide Inhibitor of Neuronal Voltage-Sensitive Calcium Channel Responses", Molecular Pharmacology, 44:451-460, May 18, 1993.
Keith et al., "Comparative Actions of Synthetic .omega.-Grammotoxin SIA and Synthetic .omega.-Aga-IVA on Neuronal Calcium Entry and Evoked Release of Neurotranmitters In Vitro and In Vivo", Nueropharmacology, (1995 Nov.) 34 (11) 1515-28.

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