Analgesic peptides from venom of grammostola spatulata and use t

Details Analgesic peptides from venom of grammostola spatulata and use t Analgesic peptides from venom of grammostola spatulata and use t

1998-02-04

1998-09-15

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530324, A61K 3817, C07K 14435

Patent

active

058078215

ABSTRACT:
The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence of SEQ ID. NO.: 1 or SEQ ID NO: 2. The invention further provides a purified peptide having the amino acid sequence of SEQ ID NO: 1. The peptides of SEQ ID NO.:1 and SEQ ID NO.: 2 can also be used in methods for identifying compounds having analgesia-inducing activity.

REFERENCES:
patent: 4925664 (1990-05-01), Jackson et al.
patent: 5064657 (1991-11-01), Jackson et al.
patent: 5122596 (1992-06-01), Phillips et al.
patent: 5196204 (1993-03-01), Jackson et al.
patent: 5281693 (1994-01-01), Jackson et al.
Lampe et al., "Isolation and Pharmacological Characterization of .omega.-Grammotoxin SIA, a Novel Peptide Inhibitor of Neuronal Voltage-Sensitive Calcium Channel Responses", Molecular Pharmacology, 44:451-460, May 18, 1993.
Keith et al. `Comparatie Actions of Synthetic .gamma.-Grammotoxin SIA an Synthetic .gamma.-Aga-IVA on Neuronal Calcium Entry and Evoked Release of Neurotransmitters In Vitro and In Vivo`, Neuropharmacology, (1995 Nov.) 34(11) 1515-28.

Affiliated with

Also associated with

Rating

Analgesic peptides from venom of grammostola spatulata and use t does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analgesic peptides from venom of grammostola spatulata and use t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analgesic peptides from venom of grammostola spatulata and use t will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-86915