Analgesic peptide and process for the preparation thereof

Details Analgesic peptide and process for the preparation thereof Analgesic peptide and process for the preparation thereof

1984-01-31

1985-11-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, C07C10352

Patent

active

045512736

ABSTRACT:
A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH.sub.2 (in which D.Ile and D.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method is also disclosed.

REFERENCES:
patent: 4218474 (1980-08-01), Barnish et al.
patent: 4396606 (1983-08-01), Goldstein
patent: 4416820 (1983-11-01), Fukuda et al.
patent: 4462941 (1984-07-01), Lee et al.
Tachibana et al., Nature, vol. 295, Jan. 28, 1982, pp. 339-340.
Huidobro-Toro, European Journal of Pharmacology, vol. 72, 1981, pp. 265-266.
Merrifield, JACS, vol. 85, 1963, pp. 2149-2154.

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