Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides

Details Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides

1990-12-18

1992-07-14

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514326, 546210, 546213, 546221, A61K 31445, C07D33306

Patent

active

051303213

ABSTRACT:
N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X, Ar, R and R.sup.1 are defined, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

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D. B. Srulevitch et al.: QSAR: Quantitative Structure-Activity Relationships in Drug Design, pp. 377-381.

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