Analgesic N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates

Details Analgesic N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates Analgesic N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates

1978-05-26

1980-01-01

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424246, 424253, 424254, 424273P, 424278, 424279, 424311, 424313, 424324, 424325, 424330, 560142, A61K 3122, A61K 31615, C07C 6708

Patent

active

041817192

ABSTRACT:
N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates I are new analgesic compounds with greatly reduced hepatotoxic effects, when taken in overdose, relative to N-acetyl-para-aminophenol. They are prepared by reacting an N-acetylaminothioalkanoic acid IV with a reactive organic chloride V to form a mixed anhydride II and then reacting the latter with N-acetyl-para-aminophenol. The mixed anhydrides II are new and useful intermediates. Alternatively the derivatives I may be prepared by reacting the acid IV with bis-(4-nitrophenyl) sulfite to form a para-nitrophenyl N-acetylaminothioalkanoic acid ester VIII, reducing the latter to a para-aminophenyl N-acetylaminothioalkanoate VII, and acetylating this product. The esters VII and VIII are new and useful intermediates. Both reactions may pass through S-blocked intermediates, which are also new. Pharmaceutical compositions containing the derivatives I are disclosed, and also analgesic methods using them.

REFERENCES:
patent: 3983138 (1976-09-01), Saari
Kovach, Dissertation Abstracts International B 1975, 36 (2), 734-735.

Affiliated with

Also associated with

Rating

Analgesic N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analgesic N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analgesic N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2120232