Analgesic N-(2-aminocycloaliphatic)benzamides

Details Analgesic N-(2-aminocycloaliphatic)benzamides Analgesic N-(2-aminocycloaliphatic)benzamides

1976-11-12

1978-07-04

Douglas, Winston A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2603322R, 260239A, 26029377, 2603264, 260329AM, 2603473, 260349, 260465D, 260505R, 260505C, 260558R, 260558S, 260558D, 260558P, 260559R, 260559T, 260559A, 424244, 424250, 424256, 424263, 424267, 424269, 424275, 424285, 424304, 424315, 544402, 544400, A61K 3104, A61K 3103, A61K 31165, C07C10382, C07C10322

Patent

active

040989046

ABSTRACT:
Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula ##STR1## E.G., N-methyl-N[2-(N-pyrrolidinyl)cyclohexyl[3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.

REFERENCES:
patent: 3373195 (1968-03-01), Pribyl et al.
patent: 3499033 (1970-03-01), Szmuszkovicz
patent: 3510492 (1970-05-01), Szmuszkovicz
patent: 3647804 (1972-03-01), Rynbrandt et al.
patent: 3825595 (1974-07-01), Roll
patent: 3847982 (1974-11-01), Herr et al.
patent: 3975443 (1976-08-01), Harper et al.
Winternitz et al., CA 50: 14574e (1956).
Brittain et al., Brit. J. Pharm., 49, pp. 158-159 (1973).
Harper et al., J. Chem. Soc. 4280 (1964).

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