Analgesic mixture of oxycodone and ibuprofen

Details Analgesic mixture of oxycodone and ibuprofen Analgesic mixture of oxycodone and ibuprofen

1985-02-11

1986-02-11

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514557, A61K 3119, A61K 3144

Patent

active

045699372

ABSTRACT:
Pharmaceutical compositions of narcotic analgesics and ibuprofen have been found to exhibit unexpectedly enhanced analgesic activity by applying an analysis model which considers data characterizing the analgesic effect of both the pure components as well as the fixed dose ratio combinations. This synergism enables the use of lower doses of either or both drugs with a concomitant reduction in risk of possible side effects.

REFERENCES:
patent: 4322427 (1982-03-01), Buyniski et al.
patent: 4489080 (1984-12-01), Loman
S. A. Cooper et al., "Relative Efficacy of an Ibuprofen-Codeine Combination", Clin. Pharmacol. Ther., 27(2), 1980, p. 249.
AMA Drug Evaluations, Fifth Ed., 1983 Chapter 4, pp. 101-102.
Pharmacotherapy, 2, No. 3, May/Jun. 1982, Cooper et al.: Analgesic Efficacy of an Ibuprofen-Codeine Combination, pp. 162-167.
Clinical Pharmacology, K. L. Melmon, M.D., et al., Chap. 11, pp. 498-499, (1972).
The Pharmacological Basis of Therapeutics, L. S. Goodman et al., 5th Ed., Chap. 17, pp. 348-349, (1975).

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