Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(

Details Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-( Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(

1982-06-30

1983-09-06

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424273R, A61K 31415, A61K 31485

Patent

active

044029624

ABSTRACT:
Pharmaceutical compositions of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole have been found to exhibit unexpectedly enhanced analgesic activity by applying an analysis model which considers data characterizing the analgesic effect of both the pure components as well as the fixed dose ratio combinations. This synergism enables the use of lower doses of either or both drugs with a concomitant reduction in risk of possible side effects.

REFERENCES:
patent: 3393197 (1968-07-01), Pachter et al.
patent: 4190666 (1980-02-01), Cherkofsky
patent: 4237140 (1980-12-01), Dudzinski
patent: 4282215 (1981-08-01), Dudzinski et al.

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