Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1973-02-02
1979-05-01
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548341, 548342, 548343, A61K 31415, C07D23304
Patent
active
041524411
ABSTRACT:
.alpha.,.alpha.-Diarylimidazole-2-methanols of the general formula ##STR1## wherein R.sub.1 -R.sub.10 are the same or different and each represents a hydrogen or halogen atom or a trifluoromethyl or tertiary butyl group, with at least one of said R.sub.1 -R.sub.10 being halogen, trifluoromethyl or tertiary butyl; R.sub.11 and R.sub.12 are the same or different and each represents a hydrogen atom, an alkyl group, a phenyl group or a halogen-or trifluoromethyl-substituted phenyl group; and R.sub.13 represents a hydrogen atom or a lower alkyl group, a lower alkoxymethyl group, a phenylalkyl group (optionally substituted in the phenyl moiety by one or more halogen atoms or alkyl or trifluoromethyl groups), an alkenyl group, a phenyl(lower)alkoxymethyl group (optionally substituted in the phenyl moiety by one or more halogen atoms or alkyl or trifluoromethyl groups) or a benzenesulfonyl group (in which the phenyl moiety is optionally substituted by one or more alkyl groups) are described. These compounds and their non-toxic acid addition salts have anorexient activity. Certain of these compounds have analgesic activity comparable to morphine but without its serious side effects. Processes for their manufacture and compositions for their use are described.
REFERENCES:
behringer et al., Chem. Ber. 1966, vol. 99, pp. 1815-1821.
Rohr et al., Chem. Ber. 1968, vol. 101, pp. 3491-3498.
Shirley et al., J. Amer. Chem. Soc., 1957, vol. 79, pp. 4922-4927.
Tertov et al., Chem. Abst., 1971, vol. 74, No. 76466e.
Hofman Petrus S.
VAN DER Stelt Cornelis
Adams Bruce L.
Burns Robert E.
Gist-Brocades N.V.
Lobato Emmanuel J.
Schwartz Richard A.
LandOfFree
Analgesic imidazolemethanols does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Analgesic imidazolemethanols, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analgesic imidazolemethanols will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-631835