Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-08-20
1998-06-16
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514168, 514365, 514561, 514562, 514617, 514643, 514646, 424601, 424600, 424678, 424680, A61K 31195, A61K 3140, A61K 31405, A61K 31415
Patent
active
057670919
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a preparation which enhances analgesic effect of analgesics. More specifically, the invention relates to a novel preparation capable of enhancing the effect of the analgesic when used in combination therewith to cancer patients or postoperative patients.
BACKGROUND ART
Heretofore there have been widely known and used various kinds of amino acid solutions supplied by means of parenteral alimentation to the patients such as cancer patients, postoperative patients and the like who are almost incapable of oral ingestion so as to achieve maintenance and improvement of the patients' physical fitness. Such known amino acid solutions are basically all alike in amino acid composition, simulating human milk, chicken eggs, human serum albumin, etc., and the composition is determined by consideration of oral alimentation to contain amino acid composition essential to the human body.
Cancer patients, postoperative patients and the like usually suffer from serious pain and these patients generally receive analgesics. However, the presently known analgesics induce side effects described below and have the problem of low effectiveness. Since cancer patients, postoperative patients and the like are in seriously bad physical conditions by invasion and even low in their drug metabolism, the analgesics are likely to produce side effects and ineffective for the treatment of chronic pain due to the development of tolerance.
(1) Narcotic and non-narcotic analgesics have problems of addiction and habituation.
(2) Several problems associated with antipyretic analgesics are reported, for example, kidney disorder caused by phenacetin, angiopathy caused by acetanilide, hepatopathy caused by aspirin, tissue disorder caused by intramuscular injection of sulpyrine, etc.
(3) Effective and safe drugs for treating chronic pain have not yet been developed due to the problem of tolerance.
Accordingly, it is an object of the present invention to provide a novel pharmaceutical preparation which can enhance analgesic effect of various kinds of analgesics when administered to cancer patients, postoperative patients and the like who receive analgesics, can control the development of tolerance associated with the repeated administration of analgesics and can reduce the side effect of analgesics, to thereby provide a highly safe total amino acid solution. It is also an object of the present invention to provide a novel pharmaceutical preparation which exerts equal or superior nutritive effect compared to the conventional nutritive amino acid solutions.
DISCLOSURE OF THE INVENTION
The inventors conducted extensive research to attain the above-mentioned objects and found that the amino acid solution which was proposed as amino acid preparation applied to cancer patients (see Japanese Examined Patent Publication No. 79049/1993) having a specified composition, in which branched amino acids and arginine are enriched, can not only exhibit excellent nutritive effect when administered to the cancer patients, postoperative patients and the like suffering from serious pain such as various central pain, cancerous pain, cluster headache, cervical syndrome or the like by supplying sufficient protein sources (amino acids), but also serve as an enhancer of analgesic effect of various analgesics when used in combination, and further found that the dosage and tolerance of the analgesics can be controlled, whereby safe and highly effective analgesic enhancing effect can be achieved. The present invention was accomplished by the above-mentioned findings.
The present invention relates to an analgesic effect enhancing preparation which potentiates the analgesic effect of analgesics, the preparation comprising as an active ingredient an amino acid composition comprising the following amino acids in the following amounts (wt %), more preferably the following suitable amounts (wt %), calculated as free amino acids.
______________________________________ Amount Suitable Amount
L-Amino acid (wt %) (wt %)
________
REFERENCES:
patent: 4871550 (1989-10-01), Millman
Kohri Hideaki
Mukai Kiyoshi
MacMillan Keith D.
Otsuka Pharmaceutical Factory Inc.
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