Analgesic dipeptide amides and method of use and compositions th

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...

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2601125E, 2601125R, A61K 3700, C07C10352

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active

044501552

ABSTRACT:
A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula R.sub.1 TyrProNR.sub.4 R.sub.5 wherein R.sub.1 is hydrogen or alkyl, R.sub.4 is phenylalkyl or substituted-phenylalkyl and R.sub.5 is hydrogen, alkyl, phenylalkyl or substituted-phenylalkyl are prepared by condensing the dipeptide with the amine or the amino acid with the amino acid amide and are useful as analgesics.

REFERENCES:
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patent: 4178371 (1979-12-01), Morgan
patent: 4261883 (1981-04-01), Smolarsky
patent: 4350627 (1982-09-01), de Castiglione et al.
patent: 4380535 (1983-04-01), Sarantakis
McGregor et al., Life Sciences, vol. 23, No. 13, pp. 1371-1376, 1978.
Roques et al., European Journal of Pharmacology, vol. 60, pp. 109-110, 1979.

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