Analgesic dipeptide amides and method of use and compositions th

Details Analgesic dipeptide amides and method of use and compositions th Analgesic dipeptide amides and method of use and compositions th

1982-09-24

1984-05-22

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125E, 2601125R, A61K 3700, C07C10352

Patent

active

044501552

ABSTRACT:
A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula R.sub.1 TyrProNR.sub.4 R.sub.5 wherein R.sub.1 is hydrogen or alkyl, R.sub.4 is phenylalkyl or substituted-phenylalkyl and R.sub.5 is hydrogen, alkyl, phenylalkyl or substituted-phenylalkyl are prepared by condensing the dipeptide with the amine or the amino acid with the amino acid amide and are useful as analgesics.

REFERENCES:
patent: 4127535 (1978-11-01), Coy et al.
patent: 4178371 (1979-12-01), Morgan
patent: 4261883 (1981-04-01), Smolarsky
patent: 4350627 (1982-09-01), de Castiglione et al.
patent: 4380535 (1983-04-01), Sarantakis
McGregor et al., Life Sciences, vol. 23, No. 13, pp. 1371-1376, 1978.
Roques et al., European Journal of Pharmacology, vol. 60, pp. 109-110, 1979.

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