Analgesic dipeptide amides and method of use and compositions th

Details Analgesic dipeptide amides and method of use and compositions th Analgesic dipeptide amides and method of use and compositions th

1982-09-24

1985-08-06

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514809, 2601125R, A61K 3700, C07C10352

Patent

active

045336555

ABSTRACT:
A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula R.sub.1 TyrR.sub.2 D-AlaNHR.sub.4 wherein R.sub.1 and R.sub.2 are each hydrogen or alkyl provided that at least one of them is other than hydrogen and R.sub.4 is phenylalkyl or substituted-phenylalkyl are prepared by condensing the dipeptide with the amine or the amino acid with the amino acid amide and are useful as analgesics.

REFERENCES:
patent: 4127535 (1978-11-01), Coy et al.
Shinagawa et al., Chem. Pharm. Bull., vol. 29, No. 12, pp. 3639-3645, 1981.
McGregor et al., Life Sciences, vol. 23, No. 13, pp. 1371-1376, 1978.
Roques et al., European Journal of Pharmacology, vol. 60, pp. 109-110, 1979.
Peptides, 2 (3), 305-307, (1981).
Peptide Chemistry, (1981), 65-68.

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