Analgesic dipeptide amides and method of use and compositions th

Details Analgesic dipeptide amides and method of use and compositions th Analgesic dipeptide amides and method of use and compositions th

1982-09-24

1984-06-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125E, A61K 3700, C07C10352

Patent

active

044541201

ABSTRACT:
A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula R.sub.1 TyrR.sub.2 D-Q-NR.sub.4 R.sub.5 wherein Q is Met, Met(O), Gln or Ser, R.sub.1 and R.sub.2 are each hydrogen or alkyl, R.sub.4 is phenylalkyl or substituted-phenylalkyl and R.sub.5 is hydrogen, alkyl, phenylalkyl, substituted-phenylalkyl or X-alkyl wherein X is an electronegative group are prepared by condensing the dipeptide with the amine or the amino acid with the amino acid amide and are useful as analgesics.

REFERENCES:
patent: 4127535 (1978-11-01), Coy et al.
patent: 4178371 (1979-12-01), Morgan
patent: 4261883 (1981-04-01), Smolarsky
patent: 4350627 (1982-09-01), de Castiglione et al.
patent: 4380535 (1983-04-01), Sarantakis
McGregor et al., Life Sciences 23, 1371-1378 (1978).
Roques et al., European J. of Pharmacology 60, (1979) 109-110.

Affiliated with

Also associated with

Rating

Analgesic dipeptide amides and method of use and compositions th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analgesic dipeptide amides and method of use and compositions th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analgesic dipeptide amides and method of use and compositions th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-121043