Analgesic dipeptide amides and method of use and composition the

Details Analgesic dipeptide amides and method of use and composition the Analgesic dipeptide amides and method of use and composition the

1982-09-24

1985-08-06

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514809, 2601125E, A61K 3700, C07C10352

Patent

active

045336571

ABSTRACT:
A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula HTyrD-AlaNR.sub.2 R.sub.3 wherein R.sub.2 is phenylalkyl or substituted-phenylalkyl and R.sub.3 is hydrogen, alkyl, phenylalkyl, substituted-phenylalkyl or X-alkyl wherein X is an electronegative moiety are prepared by condensing the dipeptide with the amine or the amino acid with the amino acid amide and are useful as analgesics.

REFERENCES:
patent: 4127535 (1978-11-01), Coy et al.
patent: 4178371 (1979-12-01), Morgan
patent: 4261883 (1981-04-01), Smolarsky
patent: 4350627 (1982-09-01), de Costiglione et al.
patent: 4380535 (1983-04-01), Sarantakis
McGregor, et al., Life Sciences, 23, 1371-1378 (1978).
Roques, et al., European J. of Pharmacology, 60, (1979) 109-110.

Affiliated with

Also associated with

Rating

Analgesic dipeptide amides and method of use and composition the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analgesic dipeptide amides and method of use and composition the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analgesic dipeptide amides and method of use and composition the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-512821