Analgesic compounds, their preparation, and pharmaceutical compo

Details Analgesic compounds, their preparation, and pharmaceutical compo Analgesic compounds, their preparation, and pharmaceutical compo

1995-01-17

1996-04-30

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142355, 5142375, 514252, 544 87, 544121, 544130, 544131, 544141, 544162, 544360, 544375, 540601, 540598, 540575, C07D26530, C07D41306, A61K 31495, A61K 3150

Patent

active

055125670

ABSTRACT:
Analgesic compounds of the formula (I); ##STR1## in which, R.sup.1 and R.sup.2 each represents hydrogen or C.sub.1 -C.sub.6 alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a heterocycle; E represents oxygen or an imino group optionally substituted with C.sub.1 -C.sub.6 alkyl or aralkyl; ring A is an aryl or heteroaryl ring, optionally substituted; R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.4 is hydrogen or R.sup.3 and R.sup.4 together represent a group of formula (IV):

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Chemical Abstracts, Blaschke et al, "Preparation, optical purity and configuration of the enantiomers of flecainide:" vol. 104, No. 11, Mar. 17, 1986, p. 644, Abstract No. 88 404j of Chem. Ber. 1985, 118(11), 4616-19.
Blaschke et al, "Herstellung, optische Reinheit und Konfiguration der Flecainid-Enantiomeren", Chem. Ber. 118(11), 4616-8619 (1985).
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