Analgesic compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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424 10, 514812, A61V 3144

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active

045828350

ABSTRACT:
A method of treating pain which comprises the administration to a patient of a parenterally or sublingually effective dose of buprenorphine together with an amount of naloxone sufficient to prevent substitution in an opiate dependent subject. Preferably when the administration is parenteral the weights of naloxone and buprenorphine are within the ratio of 1:3 to 1:1 and when administered sublingually the weights are within the ratio of 1:2 to 2:1.

REFERENCES:
Chem. Abst. 94-150268y (1984).
Chemical Abstracts 90, 145726j.
Manara et al., Dev. Neurosci, (Amsterdam) 1978, 4 (Charact. Funct. Opioids) 225-6.
Dettmar et al., Biochem. Soc. Trans. 1978, 6(5), 1004-6 (=Chem. Abs. 90, 197597n (1979).
Ramabadran et al., Endog. Exog. Opiate Agonists Antagonists, Proc. Int. Narc. Res. Club. Conf. 1979 (Pub 1980) 471-4 (-Chem. Abs. 94, 15027u (1981)).
Rance et al., Endog. Exog. Opiate Angonists Antagonists, Proc. Int. Narc. Res. Club. Conf. 1979 (Pub 1980) 387-90 (-Chem. Abs., 94, 150268y (1981)).

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