Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1992-01-08
1993-05-11
Friedman, S. J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514871, 514807, 514939, 514969, A61K 3119
Patent
active
052100995
ABSTRACT:
The invention provides an analgesic cream containing ibuprofen with superior skin penetration properties obtained in part by maintaining a pH of 4 to 7.2 such that the ibuprofen is suspended in substantially solid crystalline form.
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patent: 4545992 (1985-10-01), Kamishita
patent: 4794106 (1988-12-01), Takashima et al.
Bhala, V. H. Indian Drugs, "Transdermal Drug Delivery System for Ibuprofen", 1988, vol. 26 (3), pp. 107-111.
Gruber, K. et al. Aruzeim-Forsch/Drug Res. "Ibuprofen-Haltigen Creme", 1983, vol. 33, (II), Nr. 8, pp. 1176-1180 (with full translation).
Schaefer et al. Springer-Verlag Berlin Heidelberg N.Y. 1982, pp. 739-740.
Martin et al., Physical Pharmacy, 1983, 222-223.
Herzfeldt et al., Drug Develop. and Industrial Pharmacy vol. 9, No. 5, Aug. 1983, pp. 767-793.
Agisim Gary R.
Blank Robert G.
Chen Gloria Y.
Mody Dhiraj S.
American Home Products Corporation
Friedman S. J.
Routh John W.
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