Analgesic composition and method for alleviating pain

Details Analgesic composition and method for alleviating pain Analgesic composition and method for alleviating pain

1998-04-21

2000-04-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

424 45, 424 781, 424464, 424422, 424436, 5147723, A01N 4300, A61K 4730, A61K 3174, A61L 904, A61F 902

Patent

active

060544511

ABSTRACT:
The analgesic effectiveness of an analgesic selected from the group consisting of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine, (S)-5-(2-azetidinylmethoxy)-2-chloropyridine and pharmaceutically acceptable salts thereof is significantly potentiated by administering an analgesic-potentiating amount for said analgesic of at least one nontoxic NMDA receptor antagonist.

REFERENCES:
patent: 5055461 (1991-10-01), Kelleher et al.
patent: 5616580 (1997-04-01), Olney
patent: 5834479 (1998-11-01), Mayer et al.
Decker et al. "Antionociceptive effects of the novel neuronal nicotinic acetlcholine receptor agonist, ABT-594, in mice", European, J. Pharmacology, vol. 346, No. 1, Apr. 3, 1998, pp. 23-33.
Weisenfeld-Hallin Z, "Combined Opioid-NMDA Antagonist Therapies", vol. 55, No. 1., Jan. 1998, pp. 1-4.

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