Analgesic basic naphthalene derivatives

Details Analgesic basic naphthalene derivatives Analgesic basic naphthalene derivatives

1975-10-28

1977-12-13

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 79, 544107, 544108, 544111, 544124, 544129, 544162, 260239B, 260268B, 26029364, 2605708R, 2605705P, 2605709, A61K 51535, C07D29512

Patent

active

040629554

ABSTRACT:
Compounds of the general formula: ##STR1## wherein the groups CHR.sup.1 NR.sup.2 R.sup.3 and CHR.sup.4 NR.sup.5 R.sup.6 may be the same or different and where the group CHR.sup.4 NR.sup.5 R.sup.6 is in either the 1 or the 3 position and R.sup.1 and R.sup.4 independently represent a hydrogen atom or an aryl group;
R.sup.2, r.sup.3, r.sup.5 and R.sup.6 which may be the same or different are each a hydrogen atom or an alkyl group or an aryl group both of which may in turn be substituted by one or more hydroxy, alkoxy, acyloxy, dialkylamino or aryl groups or the groups --NR.sup.2 R.sup.3 and/or NR.sup.5 R.sup.6 represent a heterocyclic ring containing one or more hetero atoms and which ring may optionally be substituted by an alkyl, aryl or aralkyl group and in which either aromatic ring of the naphthalene nucleus may be further substituted; with the proviso that when R.sup.1, R.sup.4, R.sup.2 and R.sup.5 are hydrogen, then R.sup.3 and R.sup.6 cannot both be benzyl, when the second substituent is in the 1 position; and when R.sup.1 and R.sup.4 are hydrogen, then R.sup.2, R.sup.3, R.sup.5 and R.sup.6 cannot all be methyl when the second substituent is in the 1 position; and when R.sup.1 and R.sup.4 are hydrogen, then R.sup.2 and R.sup.3 and R.sup.5 and R.sup.6 together with the nitrogen atom cannot both be piperidino when the second substituent is in the 3 position and the naphthalene nucleus is further substituted by hydroxy in the 1 and 4 positions; and pharmaceutically acceptable salts of such compounds; and hydrates of such compounds and such salts. The compounds have activity on the central nervous system in particular as analgesics.

REFERENCES:
patent: 2040040 (1960-05-01), Bruson
Dean et al., J. Chem. Soc. pp. 2065-2069, (1968).
G. Wittig et al., Annalen, pp. 55-76, 589, (1954).
Badger et al., Nature p. 21, 162 (1948).
Gornostaeva et al., Chemical Abstracts, vol. 54, 24473h, (1960).
Reid et al., Chemical Abstracts, vol. 53, 6241f, (1959).

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