Analgesic and/or opiate antagonist tripeptide amides and process

Details Analgesic and/or opiate antagonist tripeptide amides and process Analgesic and/or opiate antagonist tripeptide amides and process

1983-02-22

1987-04-14

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Endorphin and enkephalin; related peptides

530331, 514807, C07K 712, C07K 508, A61K 3724

Patent

active

046580131

ABSTRACT:
A genus of tripeptide amides and fifteen species thereof of Examples 4-18, which are useful as analgesics and/or opiate antagonists, three processes for preparation thereof, pharmaceutical compositions thereof, and the three tripeptide amide species of Examples 1-3, which are not within the genus and are useful as analgesics and/or opiate antagonists, are disclosed.

REFERENCES:
patent: 4127534 (1978-11-01), Coy et al.
patent: 4178371 (1979-12-01), Morgan
patent: 4254023 (1981-03-01), Stewart et al.
patent: 4254024 (1981-03-01), Stewart et al.
patent: 4261883 (1981-04-01), Smolarsky
patent: 4350627 (1982-09-01), de Castigliane et al.
Vavrek et al., Abstracts of International Narcotics Research Conference, Jul. 26-30, 1981, Kyoto, Japan, Abstract P-76.

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