Analgesic and antiinflammatory derivatives of 1-acyl-4-arylalkyl

Details Analgesic and antiinflammatory derivatives of 1-acyl-4-arylalkyl Analgesic and antiinflammatory derivatives of 1-acyl-4-arylalkyl

1990-02-28

1991-04-30

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544230, 544360, 544367, 544368, 544372, 544379, 544386, 544389, 544390, 544391, C07D40312, C07D40112, C07D40512, C07D40912

Patent

active

050119281

ABSTRACT:
The reaction of N-substituted piperazines with carboxylic acids or their active derivatives such as lower-alkyl esters or the acid chlorides, leads to the formation of new piperazine carboxamides of general structural formula I: ##STR1## These compounds and the physiologically acceptable salts thereof are useful as analgesics and antiinflammatory agents.

REFERENCES:
patent: 4656175 (1987-04-01), Bjork et al.
patent: 4782086 (1988-11-01), Lunkenheimer et al.
Valenta et al., Collection Czechoslovak Chem. Commun., vol. 52, 1987, pp. 13-3023.
Yung et al., Chem. Abst., vol. 70, 47400r (1969).
Carron et al., Chem. Abst., vol. 76, 140165b (1972).
Ivanora et al., Chem. Abst., 87-33511s (1977).
Zikolova, Chem. Abst., 97-6257p (1982).
Witte et al., Chem. Abst., 99-105277t (1983).
Quittschorr et al., Chem. Abst., 104-186147x (1986).

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