Analgesic agent for newborn or fetal subjects

Details Analgesic agent for newborn or fetal subjects Analgesic agent for newborn or fetal subjects

2003-08-05

2009-12-15

Arnold, Ernst V (Department: 1616)

Drug, bio-affecting and body treating compositions

Anesthetic, general

C514S937000, C514S959000

Reexamination Certificate

active

07632872

ABSTRACT:
In a first aspect, the present invention relates to the use of xenon in the preparation of a medicament for providing analgesia in a newborn subject and/or a fetal subject. In a second aspect, the invention relates to a method of providing analgesia in a newborn subject, the method comprising administering to the subject a therapeutically effective amount of xenon. In a third aspect, the invention relates to a method of providing analgesia in a fetal subject, the method comprising administering to the mother of the fetal subject a therapeutically effective amount of xenon for both the mother and fetal subject.

REFERENCES:
patent: 5099834 (1992-03-01), Fishman
patent: 6197323 (2001-03-01), Georgieff
patent: 2002/0068764 (2002-06-01), Franks et al.
Fukura et al. (Prog. Neuro-Psychopharmacol. & Biol Psychiat. 2000, 24, 1357-1368).
Lane et al. Science 1980, 210(4472), 899-901).
Ohashi et al., “Xenon Exhibits Antinociceptive Effect on the Formalin Test in Newborn Fischer Rats”, Anesthesiology Abstracts of Scientific Papers Annual Meeting, No. 2002, 2002, pages Abstract No. A-1291, XP001155998.
Ohashi et al., “Nitrous oxide exerts age-dependent antinociceptive effects in Fischer rats”, vol. 100, No. 1-2, Nov. 2002, pp. 7-18, XP002261149.
Ohara et al., “A comparative study of the antinociceptive action of xenon and nitrous oxide in rats”, Anesthesia and Analgesia, vol. 85, No. 4, 1997, pp. 931-936, XP009020357.

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