Analgesic 5-oxygenated-6,7-benzomorphan derivatives

Details Analgesic 5-oxygenated-6,7-benzomorphan derivatives Analgesic 5-oxygenated-6,7-benzomorphan derivatives

1981-07-13

1984-01-10

Schwartz,, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

542400, 542455, 542468, 542469, 546 97, 546216, 546219, A61K 31445, C07O22126

Patent

active

044253532

ABSTRACT:
6,7-Benzomorphan derivatives of formula I, ##STR1## wherein R.sub.1 is hydrogen; optionally hydroxy- and/or alkoxy-substituted alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkylalkyl; alkenyloxyalkyl, aralkyl, arylhydroxyalkyl, aralkenyl or tetrahydrofurylalkyl; or optionally alkyl-substituted furylalkyl or isoxazolylalkyl, R.sub.2 is hydrogen or methyl, R.sub.3 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, hydroxyalkyl of alkoxyalkyl and R.sub.4 is hydrogen, hydroxy, alkoxy or alkenyloxy, hydroxy groups in said compounds being each optionally acylated, having analgesic and luteinising hormone secretion inhibiting properties.

REFERENCES:
patent: 3320265 (1967-05-01), Clarke
patent: 4087532 (1978-05-01), Merz et al.
patent: 4133888 (1979-01-01), Merz et al.
patent: 4363809 (1982-12-01), Marko et al.
Takeda, M., et al., J. Med. Chem., 13(6), 1223-1224 (1970).
Katz, R., et al., J. Med. Chem., 20(11), 1413-1419 (1977).
Rahtz, D., et al., Evr. J. Med. Chem.-Chim. Ther., 12(3), 271-278 (1977).

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