Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-05-25
1986-05-13
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
2603303, 2603309, 546 15, 549 13, 549 77, 549331, 514326, 514459, 514462, A61K 3134, A61K 3135, C07D30794, C07D31196
Patent
active
045885915
ABSTRACT:
Analgesic 2-oxa-spirocyclic compounds of the formula ##STR1## where the wavy line bonds, p, n, m, A, q, X, Y, R, R.sub.1, R.sub.2 and E are as defined in the specification, e.g., trans-4-bromo-N-methyl-N-[7-(1-pyrrolidinyl)-2-oxaspiro[4.5]dec-8-yl]benza mide, and trans-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-2-oxaspiro[4.5]dec-8-yl] benzeneacetamide, and acid addition salts thereof. Pharmaceutical compositions and methods of using these compounds as analgesics are disclosed. Processes for preparing the class of compounds are also disclosed.
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J. Org. Chem., 28, 1388 (1963), by B. T. Gillis et al.
Kaplan Lester J.
McMillan Moses W.
Kight John
Moore M. L.
Reynolds John T.
The Upjohn Company
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