Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1982-06-21
1984-03-20
Raymond, Richard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
2603303, 2603309, 424267, 424275, 424283, 424285, 546 15, 548407, 549 13, 549 77, 549331, A61K 3134, A61K 3135, C07D30794, C07D31196
Patent
active
044381301
ABSTRACT:
Mono-Oxa-, thiaspirocyclic-benzene-acetamide and -benzamide compounds of the formula ##STR1## wherein p, n, m, A, E, R, R.sub.1, R.sub.2, X, Y and Z are as defined in the specification, e.g., (.+-.)-(5.alpha.,7.alpha.,9.beta.)-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidi nyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide, and the pharmacologically acceptable salts thereof, are useful as analgesic compounds having low physical dependence liability, compared to morphine and methodone, and low dysphoria side effects. Some of these compounds have potent analgesic activity when administered orally, and some have low CNS sedative side effects. Pharmaceutical compositions and methods for using these compounds as analgesics are disclosed. Processes for preparing this class of compounds are also disclosed.
REFERENCES:
patent: 4065573 (1977-12-01), Lednicer
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4145435 (1979-03-01), Szmuszkovicz
patent: 4212878 (1980-07-01), Lednicer
Backvall, Tetra Let., No. 2, (1978), pp. 163-166.
Wittekind et al., J. Het. Chem., vol. 4, (1967), pp. 143-145.
Hodjat et al., J. Het. Chem., vol. 9, (1972), pp. 1081-1086.
Eaton et al., J. Org. Chem., vol. 37, (1972), pp. 1947-1950.
Backvall, J. Org. Chem., vol. 44, (1979), pp. 1953-1957.
Lier et al., Helv. Chim. Acta., vol. 62, (1979), p. 96.
Jeremic, Chemical Abstracts, vol. 85, (1976), 123401u.
Ross, J. Amer. Chem. Soc., vol. 69, (1947), pp. 2982-2983.
Gillis et al., J. Org. Chem., vol. 28, (1963), pp. 1388-1390.
Leonard et al., J. Org. Chem., vol. 30, (1965), pp. 821-825.
Johnson et al., J. Org. Chem., vol. 35, (1970), pp. 622-626.
Raymond Richard
Reynolds John T.
The Upjohn Company
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