Anabaseine derivatives, pharmaceutical compositions and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C546S167000, C546S256000, C546S257000

Reexamination Certificate

active

08008499

ABSTRACT:
Disclosed are novel anabaseine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.

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patent: WO 2006/133303 (2006-12-01), None
Kern, W.R., “The brain α7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21),”Behavioural Brain Research, 113:169-181 (2000).
Stokes, C. et al., “The Structural Basis for GTS-21 Selectivity between Human and Rat Nicotinic α7 Receptors,”Molecular Pharmacology, 66(1):14-24 (2004).

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